News

Articles

22 de April de 2019

BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats

Amylin analogs are important adjunctive drugs in the treatment of diabetes mellitus. However, a dual therapy with insulin involves inconvenient multiple injections. Here we describe a novel n-terminal PEGylated human amylin analog – BZ043 – and its potential to improve the control of glycemia using lower doses of insulin. The effect of BZ043 over the insulin-mediated control of fed-glycemia was investigated in rats with streptozotocin-induced diabetes treated with the basal analog glargine (GLAR). Fasted rats (3 h) received a single treatment of BZ043 (16, 64 or 128 nmol/kg), GLAR (1.5 IU or 6.0 IU) or BZ043 plus GLAR low dose (1.5 IU) in separate injections, and had free access to 5% glucose rich chow and water. BZ043 dose-proportionally prevented the meal-related increase of glycemia, and the co-treatment (64 or 128 nmol/kg) with GLAR restored normoglycemia without abrupt variations of glycemia. BZ043 showed a prolonged anti-hyperglycemic effect and, together with GLAR, promoted a long-lasting normoglycemia, in vivo. We conceive that combining BZ043 and GLAR in a fixed-ratio co-formulation might conveniently improve the control of diabetes mellitus.
 
Access the full paper co-authored by our patent specialist Caio França by clicking here.
Back

Last related news

7 de July de 2025

WTR 2025: Brazil: navigating the legal anti-counterfeiting framework as illicit trade channels evolve

Our partners Rafael Lacaz Amaral and Raquel Corrêa Barros authored the article ‘Brazil: navigating the legal anti-counterfeiting framework as illicit trade channels WTR 2025: Brazil: navigating the legal anti-counterfeiting framework as illicit trade channels evolve

Ler notícia

10 de April de 2025

Life Sciences Brazil Global Guide 2025 | Chambers & Partners

We are pleased to announce our collaboration on the Chambers and Partners Life Sciences 2025 Global Practice Guide! Our partners Priscila Kashiwabara Life Sciences Brazil Global Guide 2025 | Chambers & Partners

Ler notícia

5 de December de 2024

Check out the Advertising, Marketing & Promotion Comparative Guide for Brazil!

The Advertising, Marketing & Promotion Comparative Guide from Mondaq is now available! Mondaq invited top global experts in Marketing and Advertising Law Check out the Advertising, Marketing & Promotion Comparative Guide for Brazil!

Ler notícia
plugins premium WordPress