Articles
April 22, 2019
BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats
Amylin analogs are important adjunctive drugs in the treatment of diabetes mellitus. However, a dual therapy with insulin involves inconvenient multiple injections. Here we describe a novel n-terminal PEGylated human amylin analog – BZ043 – and its potential to improve the control of glycemia using lower doses of insulin. The effect of BZ043 over the insulin-mediated control of fed-glycemia was investigated in rats with streptozotocin-induced diabetes treated with the basal analog glargine (GLAR). Fasted rats (3 h) received a single treatment of BZ043 (16, 64 or 128 nmol/kg), GLAR (1.5 IU or 6.0 IU) or BZ043 plus GLAR low dose (1.5 IU) in separate injections, and had free access to 5% glucose rich chow and water. BZ043 dose-proportionally prevented the meal-related increase of glycemia, and the co-treatment (64 or 128 nmol/kg) with GLAR restored normoglycemia without abrupt variations of glycemia. BZ043 showed a prolonged anti-hyperglycemic effect and, together with GLAR, promoted a long-lasting normoglycemia, in vivo. We conceive that combining BZ043 and GLAR in a fixed-ratio co-formulation might conveniently improve the control of diabetes mellitus.
Access the full paper co-authored by our patent specialist Caio França by clicking here.
Last related news
February 14, 2022
Life sciences patent eligibility in Latin America: a guide
Patents are critical to the life sciences industry and often spark intense and heated debate. To be successful, one key strategy that … Life sciences patent eligibility in Latin America: a guide
October 22, 2021
Global Patent Litigation 2022 – Brazil
Our partners Claudio Barbosa and Rafael Lacaz Amaral authored a chapter about Brazil, first appeared in Global Patent Litigation Guide: Helping businesses navigate … Global Patent Litigation 2022 – Brazil
August 17, 2021
Privacy in Brazil 2021
The Q&A guide gives a high-level overview of privacy rules and principles, including what national laws regulate the right to respect for … Privacy in Brazil 2021